Publications

2023

Edri R*, Fisher S*, Menor-Salvan C, Williams LD, and Frenkel-Pinter M (2023). Assembly-Driven Protection from Hydrolysis as Key Selective Force during Chemical Evolution (2023). FEBS Letters; doi: 10.1002/1873-3468.14766.

Guth-Metzler R, Mohamed A M, Cowan ET, Henning A, Ito C, Frenkel-Pinter M, Wartell RM, Glass JB and Williams LD (2023). Goldilocks and RNA: where Mg2+ concentration is just right. Nucleic Acids Research, doi.org/10.1093/nar/gkad124

2022

C Martin* - Frenkel-Pinter M*, Smith KH, Rivera-Santana V, Sargon AB, Jacobson KC, Guzman-Martinez A, Williams LD, Leman LJ, Liotta CL, Grover MA and Hud NV (2022). Water-Based Dynamic Depsipeptide Chemistry: Building Block Recycling and Oligomer Distribution Control Using Hydration-Dehydration Cycles. JACS Au, 2, 6, 1395–1404 doi: 10.1021/jacsau.2c00087

Frenkel-Pinter M, Bouza Areces M, Fernández Facundo M, Leman LJ, Williams LD, Hud NV and Guzman-Martinez A (2022). Thioesters Provide a Plausible Prebiotic Path to Proto-Peptides. Nature communications; 11;13(1):2569 https://doi.org/10.1038/s41467-022-30191-0

Frenkel-Pinter M, Jacobson KC, Eskew-Martin J, Forsythe JG, Grover MA, Williams LD, and Hud NV (2022). Differential Oligomerization of Alpha versus Beta Amino Acids and Hydroxy Acids in Abiotic Proto-Peptide Synthesis Reactions. Life 12(2):265 https://doi.org/10.3390/life12020265

‏Frenkel-Pinter M, Petrov AS, Matange K, Travisano M, Glass JB, and Williams LD (2022). Adaptation and Exaptation: From Small Molecules to Feathers. Journal of Molecular Evolution. 90(2):166-175 https://doi.org/10.1007/s00239-022-10049-1

2021

Frenkel-Pinter M, Rajaei V, Glass JB, Hud NV and Williams LD (2021). Water and life: the medium is the message. Journal of Molecular Evolution, 89.1-2 (2021): 2-11 https://doi.org/10.1007/s00239-020-09978-6

The paper was highlighted in NewScientist.

Frenkel-Pinter M, Sargon AB, Glass JB, Hud NV and Williams LD (2021). Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine. RSC Advances 11 (6), 3534-3538 DOI: 10.1039/D0RA07965K

The paper was selected as a HOT RSC Advances article.

2020

Bowman JC, Petrov AS, Frenkel-Pinter M, Penev PI and Williams LD (2020). The Root of the Tree: Significance, Evolution and Origins of the Ribosome. Chemical Reviews; 120(11):4848-4878. doi: 10.1021/acs.chemrev.9b00742. [review article]

Frenkel-Pinter M, Haynes JW, Mohyeldin AM, C M, Sargon AB, Petrov AS, Krishnamurthy R, Hud NV, Williams LD* and Leman LJ* (2020). Mutually Beneficial Interactions Between Proto-Peptides and RNA.
Nature communications; 11(1):3137. doi: 10.1038/s41467-020-16891-5

Frenkel-Pinter M, Samanta M, Ashkenasy G* and Leman LJ* (2020). Prebiotic Peptides: Molecular Hubs in the Origin of Life. Chemical Reviews; 120(11):4707-4765. doi: 10.1021/acs.chemrev.9b00664
[review article]

Guth-Metzler R, Bray MS, Frenkel-Pinter M, Suttapitugsakul S, Montllor-Albalate C, Bowman JC, Wu R, Reddi AR, Okafor DC, Glass JB, and Williams LD (2020). Cutting in-line with iron: ribosomal function and non-oxidative RNA cleavage. Nucleic Acids Research; 48(15):8663-8674. doi: 10.1093/nar/gkaa586

Losev Y* - Frenkel-Pinter M*, Hussien MA, Viswanathan GK, Elyashiv Revivo D, Geries R, Khalaila I, Gazit E and Segal D (2020). Differential effects of putative N-glycosylation sites in human Tau on Alzheimer’s disease-related neurodegeneration. Cellular and Molecular Life Sciences; doi: 10.1007/s00018-020-03643-3

Paul A, Frenkel-Pinter M, Escobar Alvarez D, Milordini G, Gazit E, Zacco E, and Segal D (2020). Tryptophan-galactosylamine conjugates inhibit and disaggregate amyloid fibrils of Aβ42 and hIAPP peptides while reducing their toxicity. Communications biology; 3(1):484. doi: 10.1038/s42003-020-01216-5

The paper was featured as Nature’s editorial choice for the Organic Chemistry and Chemical Biology webpage and was highlighted in Nature Research Chemistry Community, on the NASA Astrobiology webpage, and in Nature.

Sun Y, Frenkel-Pinter M, Liotta CL and Grover MA (2020). The pH-dependent mechanisms of non-enzymatic peptide bond cleavage. Physical Chemistry Chemical Physics; 22, 107-113 DOI: 10.1039/C9CP05240B

2019

Frenkel-Pinter M, Haynes JW, C M, Petrov AS, Burcar BT, Krishnamurthy R, Hud NV, Leman LJ* and Williams LD* (2019). Selective Incorporation of Proteinaceous over Non-Proteinaceous Cationic Amino Acids in Model Prebiotic Oligomerization Reactions. Proceedings of the National Academy of Sciences; 116(33):16338-16346 https://doi.org/10.1073/pnas.1904849116

The paper had major media coverage, including: Popular Mechanics, Nature, Yahoo! News, Science Daily, Space Daily, Israel Space Agency,
Davidson Institute eNewsletter and Chemistry World.

Losev Y, Ashim P, Frenkel-Pinter M, Abu-Hussein M, Khalaila I, Gazit E and Segal D (2019). Novel model of secreted human tau protein reveals the impact of the abnormal N-glycosylation of tau on its aggregation propensity. Scientific reports; 9(1):2254 https://doi.org/10.1038/s41598-019-39218-x

2018

Frenkel-Pinter M, Richman M, Belostozky A, Abu-Mokh A, Gazit E, Rahimipour S and Segal D (2018). Distinct Effects of O-GlcNAcylation and Phosphorylation of a Tau-Derived Amyloid Peptide on Aggregation of the Native Peptide. Chemistry–A European Journal; 24(53):14039-14043

https://doi.org/10.1002/chem.201802209

2017

Chemerovski-Glikman M* - Frenkel-Pinter M*, Mdah R, Abu-Mokh A, Gazit E and Segal D (2017). Inhibition of the aggregation and toxicity of the minimal amyloidogenic fragment of tau by its Pro-substituted analogs. Chemistry–A European Journal; 23(40):9618-9624

https://doi.org/10.1002/chem.201701218

Frenkel-Pinter M, Shmueli M, Raz C, Yanku M, Gazit E and Segal D (2017). Interplay between protein glycosylation pathways in Alzheimer's disease. Science advances; 3(9):e1601576 DOI: 10.1126/sciadv.1601576

The paper was recommended in F1000Prime.

Frenkel-Pinter M, Stempler S, Tal S, Waldman Y, Losev Y, Ruppin E, Gazit E and Segal D (2017). Altered protein glycosylation predicts Alzheimer's disease and modulates its pathology in disease model Drosophila. Neurobiology of Aging; 56:159-171 https://doi.org/10.1016/j.neurobiolaging.2017.04.020

Frenkel-Pinter M, Tal S, Scherzer-Attali R, Abu-Hussien M, Alyagor I, Eisenbaum T, Gazit E and Segal D (2017). Cl-NQTrp alleviates tauopathy symptoms in a model organism through inhibition of tau aggregation-engendered toxicity. Neurodegenerative Diseases; - - - - 17(2-3):73-82 https://doi.org/10.1159/000448518

2016

Frenkel-Pinter M, Raz C, Gazit E and Segal D (2016). Boiling reduces glycan detection of glycoproteins. CIBTech Journal of Bio-Protocols; 5 (1), 4-8

Frenkel-Pinter M, Richman M, Belostozky A, Abu-Mokh A, Gazit E, Rahimipour S and Segal D (2016). Selective inhibition of aggregation of amyloidogenic Tau-derived peptide using its glycosylated analogs. Chemistry–A European Journal; 22(17):5945-52 https://doi.org/10.1002/chem.201504950

Inside cover of Chemistry (Volume 22, Issue 17).

Frenkel-Pinter M, Tal S, Scherzer-Attali R, Abu-Hussien M, Alyagor I, Eisenbaum T, Gazit E and Segal D (2016). Naphthoquinone-tryptophan hybrid inhibits aggregation of the tau-derived peptide PHF6 and reduces neurotoxicity. Journal of Alzheimer's Disease; 51(1):165-78 DOI: 10.3233/JAD-150927

2013

Shaltiel-Karyo R* - Frenkel-Pinter M*, Rockenstein E, Patrick C, Egoz-Matia N, Masliah E, Segal D and Gazit E (2013). A BBB disrupter is also a potent α-synuclein aggregation inhibitor: A novel dual mechanism of mannitol for the treatment of Parkinson’s disease. Journal of Biological Chemistry; 288(24):17579-88 DOI: https://doi.org/10.1074/jbc.M112.434787

The paper had major media coverage, including: Popular Science, MedicalNewsToday, and Science Daily.

2012

Shaltiel-Karyo R, Davidi D, Frenkel-Pinter M, Ovadia M, Segal D and Gazit E (2012). Differential inhibition of α-synuclein oligomeric and fibrillar assembly by cinnamon extract. Biochimica et Biophysica Acta (BBA)-General Subjects; 1820(10):1628-35 https://doi.org/10.1016/j.bbagen.2012.04.021

Shaltiel-Karyo R, Davidi D, Menuchin Y, Frenkel-Pinter M, Marcus-Kalish M, Ringo J, Gazit E and Segal D (2012). A novel, sensitive assay for behavioral defects in Parkinson’s disease model Drosophila. Parkinson’s disease; Volume 2012, Article ID 697564 https://doi.org/10.1155/2012/697564

2011

Drug E, Landesman-Milo D, Belgorodsky B, Ermakov N, Frenkel-Pinter M, Fadeev L, Peer D, and Gozin M (2011). Enhanced Bioavailability of Polyaromatic Hydrocarbons in the Form of Mucin Complexes. Chemical research in toxicology; 24(3):314-20 https://doi.org/10.1021/tx100426s

2011

2010

Shaltiel-Karyo R, Frenkel-Pinter M, Egoz-Matia N, Frydman-Marom A, Shalev DE, Segal D and Gazit E (2010). Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype recovery of Parkinson's disease model flies. PLoS One; 5(11): e13863 https://doi.org/10.1371/journal.pone.0013863