2026

Edri, R., Fisher, S., Levi-Kalisman, Y. and Frenkel-Pinter M. Hydroxy acid conjugation to lipids increases structural and hydrolytic stability. Nat Commun 17, 6973 (2026). https://doi.org/10.1038/s41467-026-75192-5

Akulenko, D., Edri, R. & Frenkel-Pinter, M. Metal ions affect abiotic sugar oligomerization reactions. Commun Chem (2026). https://doi.org/10.1038/s42004-026-02129-w

Ezerzer Y, Hiregange DG, Bashan A, Yonath A, Frenkel-Pinter M. (2026) Shared Pathways to Peptides in Biochemistry and Prebiotic Chemistry through Ester Amide Exchange Chemistry. BioCosmos The Israel Biocomplexity Center, 6, no. 1 19-24. https://doi.org/10.2478/biocosmos-2026-0002

Capera-Aragones P, Matange K, Rajaei V, Pinter Y, Petrov AS, Williams LD, and Frenkel-Pinter M (2026). Stringent Selection on Kinetics of Condensation Reactions: Early Steps in Chemical Evolution. Phys. Chem. Chem. Phys. (2026) 28, 7292-7303. https://doi.org/10.1039/D5CP03057A

Marland E., Lipson, G., Edri, R., Cohen, Or, Guzman-Martinez, A., Shalev, O., Salvan, C. M., and Frenkel-Pinter, M. (2026). Robust Synthesis of Prebiotic Precursors in Drying Reactions of Amino Acids and Keto Acids. ChemSystemsChem; https://doi.org/10.1002/syst.202500018

2025

Fisher, S., Ezerzer, Y., Edri, R., Akulenko, D., Marland, E., and Frenkel-Pinter, M. (2025). Protopeptide backbone affects assembly in aqueous solutions. Proceedings of the National Academy of Sciences; doi.org/10.1073/pnas.250050312

Matange, K., Rajaei, V., Capera-Aragonès. P., Costner, J.T., Robertson, A., Kim, J.S., Petrov, A.S., Bowman, J.C., Williams, L.D., and Frenkel-Pinter, M. (2025). Evolution of Complex Chemical Mixtures Reveals Combinatorial Compression and Population Synchronicity. Nature Chemistry; doi.org/10.1038/s41557-025-01734-x.

Edri, R., Joshi, M.P., Frenkel-Pinter, M., Hud, N.V., Keating, C.D., and Leman, L.J. (2025). From polymerization-enabled folding and assembly to chemical evolution: key processes for emergence of functional polymers in the origin of life. Astrobiology; doi.org/10.1177/15311074251365943

Matange, K., Marland, E., Frenkel-Pinter, M., and Williams, L.D. (2025). Biological Polymers: Evolution, Function, and Significance. Accounts of Chemical Research doi.org/10.1021/acs.accounts.4c00546

Ezerzer, Y., Frenkel-Pinter, M., Kolodny, R., and Ben-Tal, N. (2025). A building blocks perspective on protein emergence and evolution. Current Opinion in Structural Biology; doi.org/10.1016/j.sbi.2025.102996

2024

Edri, R., Williams, L.D., and Frenkel-Pinter, M (2024). From Catalysis of Evolution to Evolution of Catalysis. Accounts of Chemical Research, 16338-16346 doi.org/10.1021/acs.accounts.4c00196

2023

Edri R*, Fisher S*, Menor-Salvan C, Williams LD, and Frenkel-Pinter M (2023). Assembly-Driven Protection from Hydrolysis as Key Selective Force during Chemical Evolution . FEBS Letters; doi: 10.1002/1873-3468.14766.

Guth-Metzler R, Mohamed A M, Cowan ET, Henning A, Ito C, Frenkel-Pinter M, Wartell RM, Glass JB and Williams LD (2023). Goldilocks and RNA: where Mg2+ concentration is just right. Nucleic Acids Research, doi.org/10.1093/nar/gkad124

2022

C Martin* - Frenkel-Pinter M*, Smith KH, Rivera-Santana V, Sargon AB, Jacobson KC, Guzman-Martinez A, Williams LD, Leman LJ, Liotta CL, Grover MA and Hud NV (2022). Water-Based Dynamic Depsipeptide Chemistry: Building Block Recycling and Oligomer Distribution Control Using Hydration-Dehydration Cycles. JACS Au, 2, 6, 1395–1404 doi: 10.1021/jacsau.2c00087

Frenkel-Pinter M, Bouza Areces M, Fernández Facundo M, Leman LJ, Williams LD, Hud NV and Guzman-Martinez A (2022). Thioesters Provide a Plausible Prebiotic Path to Proto-Peptides. Nature communications; 11;13(1):2569 https://doi.org/10.1038/s41467-022-30191-0

Frenkel-Pinter M, Jacobson KC, Eskew-Martin J, Forsythe JG, Grover MA, Williams LD, and Hud NV (2022). Differential Oligomerization of Alpha versus Beta Amino Acids and Hydroxy Acids in Abiotic Proto-Peptide Synthesis Reactions. Life 12(2):265 https://doi.org/10.3390/life12020265

‏Frenkel-Pinter M, Petrov AS, Matange K, Travisano M, Glass JB, and Williams LD (2022). Adaptation and Exaptation: From Small Molecules to Feathers. Journal of Molecular Evolution. 90(2):166-175 https://doi.org/10.1007/s00239-022-10049-1

2021

Frenkel-Pinter M, Rajaei V, Glass JB, Hud NV and Williams LD (2021). Water and life: the medium is the message. Journal of Molecular Evolution, 89.1-2 (2021): 2-11 https://doi.org/10.1007/s00239-020-09978-6

Frenkel-Pinter M, Sargon AB, Glass JB, Hud NV and Williams LD (2021). Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine. RSC Advances 11 (6), 3534-3538 DOI: 10.1039/D0RA07965K

2020

Bowman JC, Petrov AS, Frenkel-Pinter M, Penev PI and Williams LD (2020). The Root of the Tree: Significance, Evolution and Origins of the Ribosome. Chemical Reviews; 120(11):4848-4878. doi: 10.1021/acs.chemrev.9b00742. [review article]

Frenkel-Pinter M, Haynes JW, Mohyeldin AM, C M, Sargon AB, Petrov AS, Krishnamurthy R, Hud NV, Williams LD* and Leman LJ* (2020). Mutually Beneficial Interactions Between Proto-Peptides and RNA. Nature communications; 11(1):3137. doi: 10.1038/s41467-020-16891-5

Frenkel-Pinter M, Samanta M, Ashkenasy G* and Leman LJ* (2020). Prebiotic Peptides: Molecular Hubs in the Origin of Life. Chemical Reviews; 120(11):4707-4765. doi: 10.1021/acs.chemrev.9b00664 [review article]

Guth-Metzler R, Bray MS, Frenkel-Pinter M, Suttapitugsakul S, Montllor-Albalate C, Bowman JC, Wu R, Reddi AR, Okafor DC, Glass JB, and Williams LD (2020). Cutting in-line with iron: ribosomal function and non-oxidative RNA cleavage. Nucleic Acids Research; 48(15):8663-8674. doi: 10.1093/nar/gkaa586

Losev Y* - Frenkel-Pinter M*, Hussien MA, Viswanathan GK, Elyashiv Revivo D, Geries R, Khalaila I, Gazit E and Segal D (2020). Differential effects of putative N-glycosylation sites in human Tau on Alzheimer’s disease-related neurodegeneration. Cellular and Molecular Life Sciences; doi: 10.1007/s00018-020-03643-3

Paul A, Frenkel-Pinter M, Escobar Alvarez D, Milordini G, Gazit E, Zacco E, and Segal D (2020). Tryptophan-galactosylamine conjugates inhibit and disaggregate amyloid fibrils of Aβ42 and hIAPP peptides while reducing their toxicity. Communications biology; 3(1):484. doi: 10.1038/s42003-020-01216-5

Sun Y, Frenkel-Pinter M, Liotta CL and Grover MA (2020). The pH-dependent mechanisms of non-enzymatic peptide bond cleavage. Physical Chemistry Chemical Physics; 22, 107-113 DOI: 10.1039/C9CP05240B

2019

Frenkel-Pinter M, Haynes JW, C M, Petrov AS, Burcar BT, Krishnamurthy R, Hud NV, Leman LJ* and Williams LD* (2019). Selective Incorporation of Proteinaceous over Non-Proteinaceous Cationic Amino Acids in Model Prebiotic Oligomerization Reactions. Proceedings of the National Academy of Sciences; 116(33):16338-16346 https://doi.org/10.1073/pnas.1904849116

Losev Y, Ashim P, Frenkel-Pinter M, Abu-Hussein M, Khalaila I, Gazit E and Segal D (2019). Novel model of secreted human tau protein reveals the impact of the abnormal N-glycosylation of tau on its aggregation propensity. Scientific reports; 9(1):2254 https://doi.org/10.1038/s41598-019-39218-x

2018

Frenkel-Pinter M, Richman M, Belostozky A, Abu-Mokh A, Gazit E, Rahimipour S and Segal D (2018). Distinct Effects of O-GlcNAcylation and Phosphorylation of a Tau-Derived Amyloid Peptide on Aggregation of the Native Peptide. Chemistry–A European Journal; 24(53):14039-14043 https://doi.org/10.1002/chem.201802209

2017

Chemerovski-Glikman M* - Frenkel-Pinter M*, Mdah R, Abu-Mokh A, Gazit E and Segal D (2017). Inhibition of the aggregation and toxicity of the minimal amyloidogenic fragment of tau by its Pro-substituted analogs. Chemistry–A European Journal; 23(40):9618-9624 https://doi.org/10.1002/chem.201701218

Frenkel-Pinter M, Shmueli M, Raz C, Yanku M, Gazit E and Segal D (2017). Interplay between protein glycosylation pathways in Alzheimer's disease. Science advances; 3(9):e1601576 DOI: 10.1126/sciadv.1601576

Frenkel-Pinter M, Stempler S, Tal S, Waldman Y, Losev Y, Ruppin E, Gazit E and Segal D (2017). Altered protein glycosylation predicts Alzheimer's disease and modulates its pathology in disease model Drosophila. Neurobiology of Aging; 56:159-171 https://doi.org/10.1016/j.neurobiolaging.2017.04.020

Frenkel-Pinter M, Tal S, Scherzer-Attali R, Abu-Hussien M, Alyagor I, Eisenbaum T, Gazit E and Segal D (2017). Cl-NQTrp alleviates tauopathy symptoms in a model organism through inhibition of tau aggregation-engendered toxicity. Neurodegenerative Diseases; 17(2-3):73-82 https://doi.org/10.1159/000448518

2016

Frenkel-Pinter M, Raz C, Gazit E and Segal D (2016). Boiling reduces glycan detection of glycoproteins. CIBTech Journal of Bio-Protocols; 5 (1), 4-8

Frenkel-Pinter M, Richman M, Belostozky A, Abu-Mokh A, Gazit E, Rahimipour S and Segal D (2016). Selective inhibition of aggregation of amyloidogenic Tau-derived peptide using its glycosylated analogs. Chemistry–A European Journal; 22(17):5945-52 https://doi.org/10.1002/chem.201504950

Frenkel-Pinter M, Tal S, Scherzer-Attali R, Abu-Hussien M, Alyagor I, Eisenbaum T, Gazit E and Segal D (2016). Naphthoquinone-tryptophan hybrid inhibits aggregation of the tau-derived peptide PHF6 and reduces neurotoxicity. Journal of Alzheimer's Disease; 51(1):165-78 DOI: 10.3233/JAD-150927

2013

Shaltiel-Karyo R* - Frenkel-Pinter M*, Rockenstein E, Patrick C, Egoz-Matia N, Masliah E, Segal D and Gazit E (2013). A BBB disrupter is also a potent α-synuclein aggregation inhibitor: A novel dual mechanism of mannitol for the treatment of Parkinson’s disease. Journal of Biological Chemistry; 288(24):17579-88 DOI: https://doi.org/10.1074/jbc.M112.434787

2012

Shaltiel-Karyo R, Davidi D, Frenkel-Pinter M, Ovadia M, Segal D and Gazit E (2012). Differential inhibition of α-synuclein oligomeric and fibrillar assembly by cinnamon extract. Biochimica et Biophysica Acta (BBA)-General Subjects; 1820(10):1628-35 https://doi.org/10.1016/j.bbagen.2012.04.021

Shaltiel-Karyo R, Davidi D, Menuchin Y, Frenkel-Pinter M, Marcus-Kalish M, Ringo J, Gazit E and Segal D (2012). A novel, sensitive assay for behavioral defects in Parkinson’s disease model Drosophila. Parkinson’s disease; Volume 2012, Article ID 697564 https://doi.org/10.1155/2012/697564

2011

Drug E, Landesman-Milo D, Belgorodsky B, Ermakov N, Frenkel-Pinter M, Fadeev L, Peer D, and Gozin M (2011). Enhanced Bioavailability of Polyaromatic Hydrocarbons in the Form of Mucin Complexes. Chemical research in toxicology; 24(3):314-20 https://doi.org/10.1021/tx100426s

2010

Shaltiel-Karyo R, Frenkel-Pinter M, Egoz-Matia N, Frydman-Marom A, Shalev DE, Segal D and Gazit E (2010). Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype recovery of Parkinson's disease model flies. PLoS One; 5(11): e13863 https://doi.org/10.1371/journal.pone.0013863